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However, about 10-15% of acetaminophen is metabolized by CYP2E1 into a toxic metabolite known as NAPQI (N-acetyl-p-benzoquinone imine).[ref] Detoxification with glutathione: NAPQI then needs to be neutralized with glutathione, which is catalyzed using the GST genes

PMID 7060551

A.BasudharD.SomasundaramV.McVicarD

Furthermore, we treated dividing and senescent cells with 20 M of CPP-CAND and assessed caspase 3/7 activity to examine whether the apoptosis observed was caspase-dependent