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Glutathione is compartmentalized throughout the cell, with 80-85% in the cytosol, 10-15% in mitochondria, and smaller amounts in the endoplasmic reticulum, nucleus, and peroxisomes
These features may mean that covalent inhibitors are required for inhibition of cellular GPX4, which often have poor selectivity and pharmacokinetic properties
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This inhibition leads to elevated circulating levels of VLDL and TG, impairing lipid clearance and metabolic balance [223]
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