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The immunological impact of the two Met(O) for Met substitutions present in this impurity could be studied in ex vivo T cell induction assays

GLP-1/GLP-1RAs have been shown to affect both basal and reward-related feeding, and increase dopamine transporter levels (202, 203)

p-eIF4E staining was done using mouse anti-elF4E (pS209) (BD 560229) diluted 1:100 and cells were fixed with BD Cytofix/Perm and intracellular staining was done in BD Perm (BD 554714)

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