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Historically, LT for ALD has been controversial, partly due to perceptions of ALD being a self-inflicted condition [106]

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These peptides work on the growth hormone system, while testosterone hormone replacement therapy works on testosterone levels, so they target different hormones and can complement each other

The pathophysiology is unclear, but risk factors are thought to be the same as the type 1 diabetic patients who rapidly improved A1c in the Diabetes Control and Complications Trial: long duration of diabetes mellitus, long duration of poor glycemic control, worse baseline level of DR prior to treatment and magnitude of reduction in A1c after treatment