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Some patients feel differences within the first few weeks, though more noticeable weight loss typically happens once youve moved up to higher doses

The mutant receptors also recover faster from desensitized state compared to wild-type with rec of 0.3 s (**P = 0.0028) and 0.6 s (*P = 0.0465) for E239L and Y243F respectively

Cardiovascular benefit of oral semaglutide in patients with T2DM and established atherosclerotic cardiovascular diseases and/or chronic kidney disease is currently under investigation in SOUL (Semaglutide cardiovascular outcomes) trial (45)