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[1] In moderate deficiencies, feeling tired, feeling faint, mouth ulcers, rapid breathing, upset stomach, pallor, hair loss, decreased ability to think and joint pain and the beginning of neurological symptoms, including abnormal sensations such as, numbness and tingling, and tinnitus may occur

By evaluating the durability of response over an extended period, researchers can assess whether alternative therapies, such as steroids, vitamin D analogs, and calcineurin inhibitors, provide sustained benefits and how they compare to traditional topical treatments