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Cognitive improvement was observed after 8 weeks of treatment in both females and males, sustained through a 12-week study period, and accompanied by a concurrent reduction in amyloid plaques and neuroinflammation compared to intranasal saline-treated transgenic mice

Further, this study provides new evidence that mitochondrial superoxide production may be elevated in certain brain regions and that a neuroinflammatory process may promote oxidative stress and damage in affected cells

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10.1016/j.tips.2009.08.003 195 YoshidaT.AkahoshiF.SakashitaH.KitajimaH.NakamuraM.SondaS.et al (2012)