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For example, homocysteine-induced endoplasmic reticulum protein, which is located in the ER membrane of neurons and astrocytes in the Central Nervous System (SNC), is found accumulated in Lewy bodies, suggesting a role in their formation and further development of PD [117]

This H-bonding network in canonical PDOs prevents the active-site water molecule from participating in the oxidation of the persulfide product, leading only to the formation of an RSSO 2 - intermediate, which is then hydrolyzed by an external water molecule to release sulfite 40

Shoukier M, Konopleva M, DiNardo CD, Ravandi F, Andreeff M , Garcia-Manero G, Jabbour E, Daver NG, Borthakur G, Pemmaraju N, Montalban-Bravo G, Benton CB, Short NJ, Bhalla KN, Cortes, JE, Kantarjian HM, Kadia TM

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