mice lacking prolactin receptors showed a significant reduction in adipose tissue mass and the number of adipocytes ( in vitro experiments have shown that prolactin receptor (PRLR) gene expression is significantly upregulated during the differentiation of preadipocytes into mature adipocytes, with an approximately 90-fold increase, supporting the functional role of prolactin signaling in adipocyte development and lipid accumulation ( In rodent models, pathological hyperprolactinemia also significantly affects brown adipose tissue (BAT), manifested as the downregulation of thermogenic markers, BAT whitening, and impaired adaptive thermogenesis
Visual inspection for particulate matter or discoloration is required before administration
Anxiety: Clonidine's calming effect on the central nervous system can aid in alleviating anxiety symptoms
doi: 10.3389/fphar.2025.1698734 Received 04 September 2025 Revised 16 December 2025 Accepted 17 December 2025 Published 12 January 2026 Volume 16 - 2025 Edited by Man Sau Wong, Hong Kong Polytechnic University, Hong Kong SAR, China Reviewed by Zahra Hoseini Tavassol, Tehran University of Medical Sciences, Iran Soroush Taherkhani, Iran University of Medical Sciences, Iran Updates Copyright 2026 Fu, Peng, Yu, Cao, Zheng and Wu
