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No official contraindication or direct drug interaction exists between semaglutide and typical cold remedy ingredients, though Wegovy's gastrointestinal side effects may be worsened by multi-symptom products, and total paracetamol intake must not exceed 4 g in 24 hours

Activation of endogenous GLP-1 neurons in the hindbrain is sufficient to reduce cocaine seeking in rodents (Merkel et al., 2025)

Weight loss with GLP-1 therapy alone averages 1015% of baseline body weight over 68 weeks in clinical trials, with some patients achieving 20% or greater reductions

And it is important that the clinician acknowledge it and not pretend that having too much body fat is benign