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Researchers should also consider the contraindications for semaglutide, including: History of thyroid cancer Multiple endocrine neoplasia syndrome type 2 (MEN 2) Pregnancy Lactation Known allergy to semaglutide Animal studies suggest that GLP-1-RAs, including semaglutide, could lead to reduced embryo size and developmental anomalies

which have given consistent results

Their insights provide valuable context for understanding the drugs potential and the importance of continued research and development

For example, moderate elevations in liver enzymes, bilirubin, and glucose are present in approximately 50% of cases and hypocalcemia in approximately two of three of cases