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Currently, there is a lack of systematic toxicity evaluation data regarding their systemic effects, and it is urgent to establish an AMPK pathway-dependent toxicity early warning model to ensure the safety of clinical application by assessing the potential effects of natural product metabolites on extrahepatic organs

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Gold particle-coupled secondary antibodies were diluted at a ratio of 1:50, followed by post-staining with aqueous uranyl acetate and lead citrate