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However, despite these promising advantages, clinical research is still limited, and FDA approval has not been granted

There were no cases of glucose intolerance, insulin resistance, edema (fluid retention), joint pain, carpal tunnel syndrome, or other manifestations of excess growth hormone activity

[2] Use of estradiol cypionate injection is contraindicated in individuals with undiagnosed abnormal vaginal bleeding, known or suspected breast cancer or other estrogen-dependent neoplasia, active or prior venous thromboembolism, recent arterial thrombo-occlusive disease such as stroke or myocardial infarction, severe hepatic impairment, a history of hypersensitivity to estradiol or any excipients, and in those who are or may become pregnant