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Originally developed to treat diabetes, GLP-1 medications have become synonymous with weight loss, with usage increasing rapidly both through prescriptions for clinical obesity treatment and off-label private sales for cosmetic weight loss

Conversely, semaglutide isn't suitable for individuals with medullary thyroid carcinoma, multiple endocrine neoplasia, a history of pancreatitis, or severe gastrointestinal issues

Temperature control tips during travel: Short trips (under 28 days): Use a simple insulated bag with a cold pack (not directly touching the pen) to keep it below 86F (30C)

The distinction matters because pulsatile GH secretion triggers downstream benefits (lipolysis, collagen synthesis, immune modulation) that constant IGF-1 elevation doesn't replicate