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While synergistic benefits are mechanistically plausible, direct clinical trials on combined supplementation remain limited, and cost factors must be balanced against targeted outcomes

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USA 109 , 43204325 (2012)

The compound reliably raised GH and IGF-1, but the two largest or longest trials the Alzheimers study and the two-year healthy-elderly study failed to show benefit on the outcomes that actually matter (cognition/function and strength/function, respectively)