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One way is that it is responsible for maintaining the supply of glutathione, one of the important antioxidants that your body produces to counteract oxidative stress.[ref] G6PD Deficiency Inheritance Mutations in the G6PD gene can cause the glucose-6-phosphate dehydrogenase enzyme not to function properly

CB-839 is a highly potent allosteric inhibitor that completed phase I clinical trials in March 2019 in patients with advanced RCC (NCT02071862) and has in 2020 moved to phase II clinical trials in patients with non-small cell lung cancer (NCT04265534)

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Moreover, evidence has emerged that a link exists between glutathione (GSH) metabolism and the epigenetic regulation of redox phenomena 3,4