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The SIF was a commercially available product formulated according to pharmacopeial guidelines, consisting primarily of potassium dihydrogen phosphate (KHPO), sodium hydroxide for pH adjustment, and purified water, without digestive enzymes

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Causes and Risk Factors Impaired peristalsis (wave-like contractions of the gut) Blockages, neurological and hormonal conditions, and medications such as opioids Female gender (two to three times the risk of males) and advanced age (with greatest prevalence in those older than 70) Diagnosis Diagnosis is based on bowel habits, symptoms, and medical history