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Second, PVN innervates the pituitary (PIT) portal system to achieve neuroendocrine regulatory effects [47, 48]
In particular PC1/3 expressing cells, such as intestinal L-cells and pancreatic -cells, produce GLP-1, GLP-2 oxyntomodulin and glicentin (110, 112), while PC2 action on PG results in the production of glucagon and its active metabolite mini-glucagon (113, 114)
Stage 2 presents as a firm mound extending beyond the areola with little to no skin sagging, giving the nipple a puffy or protruding appearance while the surrounding skin still retains good elasticity
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