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The cell membrane is composed of a phospholipid bilayer structure, and the phospholipid heads of the hydrophobic layer are easily damaged by oxidation 2

Moreover, a reversed GSH redox state and activity-suppressed GPX have been observed in the myocardium of various myocardial injury animal models [40,41,42,43]

In vitro proximal tubule nephrotoxicity testing will evaluate the compounds renal safety profiles, significantly accelerating drug safety studies