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Estrogen directly regulates neuronal glucose metabolism through estrogen receptor-beta in the brain, and its loss creates an energy deficit in regions most vulnerable to Alzheimer's pathology

One further comparison point is often glossed over: the injectable ghrelin-mimetic peptides and the GHRH analogs act on different receptors , which is why they are sometimes studied together in the research literature a GHRH-receptor agent and a ghrelin-receptor agent can produce a larger combined GH response than either alone, because they engage two independent limbs of the same regulatory system

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The drug is contraindicated during pregnancy [4]