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Initial treatment for B12 deficiency with neurological involvement: When elderly patients present with neurological symptoms (peripheral neuropathy, cognitive impairment, subacute combined degeneration of the cord), urgent and aggressive replacement is essential to prevent irreversible damage

While the pathways are well elucidated and the fine details of their molecular mechanisms are beyond the scope of this manuscript, it is worth noting that not all patients suffer the same fate when it comes to APAP ingestion and hepatotoxicity

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