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Nausea is most pronounced during dose escalation windows, particularly around weeks six to eight when doses are increasing, and typically diminishes substantially by week twelve as tolerance develops

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Insulin resistance: A 2012 study found that TB-500 ameliorates hyperglycemia and improves insulin resistance in a mouse model of type 2 diabetes mellitus (T2DM), indicating that it may be an alternative insulin sensitizer [7]

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