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Nevertheless, This study provides the first evidence of a formulation-and dose-dependent ION risk, with the strongest association observed for Wegovy, write the researchers, concluding: These findings highlight a potential dose-dependent safety concern that warrants urgent prospective evaluation to guide prescribing and regulatory policy. The authors of a linked commentary agree

319 Thus, LSD1 suppresses autophagy through H3K4 demethylation and LC3B destabilization, and its inhibition has therapeutic potential in oncology and reproductive medicine

In June 2023, the American Society of Anesthesiologists (ASA) issued consensus-based guidance warning that GLP-1 drugs can delay gastric emptying and may increase the risk of regurgitation and pulmonary aspiration (stomach contents entering the respiratory system) during anesthesia