Research interest in BPC-157 has expanded considerably due to its demonstrated effects in numerous animal models, showing potential in tissue repair, wound healing, and organ protection
SCFA are considered as possible mediators of the communication between gut microbiota and the brain (Dalile et al., 2019)
In an open-label, phase 3, multicenter study involving 11 children aged 25 years with biallelic POMC, PCSK1, or LEPR variants, or genetically confirmed BardetBiedl syndrome (BBS), 83% achieved a 0.2-point reduction in BMI Z score over 52 weeks, with a mean BMI reduction of 18% observed overall (26% in the POMC/LEPR group and 10% in the BBS group) [45]
Combining leptin treatment with leptin sensitizers may thus help overcome leptin resistance and, also obesity, as a result [14]