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76,77 The mechanisms through which this occurs are not fully elucidated, although basic science and clinical studies have shown that GLP-1 agonists have immunomodulatory effects by reducing proinflammatory cytokines and altering immune cell populations

In a statement, lawyers for Monarez said that Kennedy had been "weaponizing public health for political gain" and "putting millions of American lives at risk"

Cardiovascular Protection : Clinical evidence suggests it helps reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes and established heart disease

A summary of clinically-significant GLP-1RAs described in this text and their clinical uses are listed in Table 1