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This was achieved by inhibiting bone resorption through an increase in the OPG/RANKL ratio and promoting bone formation by enhancing the expression of osteoblast-specific transcription factors
Phase 2: Expands to a few hundred people to see if the drug actually works for its intended purpose, while still tracking side effects
Patients with rheumatoid arthritis should not consider GLP-1 agonists as an alternative to established disease-modifying antirheumatic drugs (DMARDs) or biologic therapies
For weight management, lack of at least 5% weight loss by 12 weeks at the maintenance dose warrants discussion about alternative strategies or dose optimization
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