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European Journal of Pharmacology, 833, 274289
When semaglutide enters subcutaneous tissue, it creates a localized osmotic gradient that triggers nerve irritation in the injection area
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Malonyl-CoA:acyl-carrier protein acyltransferase (MCAT) transfers the malonyl group to the acyl-carrier-protein (ACP) [29], followed by a series of enzymatic reactions: condensation to 3-ketoacyl-ACP by 3-oxoacyl-acyl-carrier-protein synthase (OXSM) [30], reduction to 3-hydroxyacyl-ACP by 3-oxoacyl-acyl-carrier-protein reductase [31], dehydration of 3-hydroxyacyl-ACP by 3-hydroxyacyl-thioester dehydratase to 2-trans-enoyl-ACP [32,33], and a final reduction by trans-2-enoyl-CoA reductase which catalyzes the reduction of 2-transenoyl-ACP to acyl-ACP [34]
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