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Wadden, Thomas et al Tirzepatide after intensive lifestyle intervention in adults with overweight or obesity: the SURMOUNT-3 phase 3 trial

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Nuclear magnetic resonance spectroscopy analysis shows reduced peaks of choline and inositol

The aortic ring assay (ex vivo sprouting from rat aortic rings embedded in Matrigel), Matrigel plug assay (in vivo CD31-stained vessel density), and HUVEC tube formation assay (Angiogenesis Analyser quantification) all demonstrate robust, reproducible BPC-157-driven angiogenesis