In 87% ( n = 277) of randomized participants, liver biopsy at week 72 was available to evaluate the primary endpoint of resolution of MASH and the confirmatory secondary endpoint of improvement of at least one fibrosis stage and no worsening of MASH
Nausea is the most common side effect, affecting 20 to 44% of users across GLP-1 medications per FDA prescribing information for Wegovy, Zepbound, and Ozempic
Another study found that up-regulation of Bnip3/Nix by Fucoxanthin (FX) enhances mitophagy and reduces oxidative stress, ameliorates myocardial fibrosis, and attenuates HG-induced hypertrophy of H9C2 cells in diabetic rats and HG-induced H9C2 cells in STZ-induced diabetic rat models [173].In addition, in STZ-induced Sirt3 KO mouse and primary neonatal mouse cardiomyocyte models, Sirt3 was found to exert cardioprotective effects on DCM through activation of Foxo3A-Parkin-mediated mitophagy [181]
Por tanto, la DM2 no es solo un serio problema de salud pblica, sino tambin un enorme problema econmico que puede ser especialmente grave para pases de economas dbiles como los latinoamericanos