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Cell (1992) 70(2):31322.10.1016/0092-8674(92)90105-L 58 NosakaTvan DeursenJMTrippRAThierfelderWEWitthuhnBAMcMickleAPet alDefective lymphoid development in mice lacking Jak3

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The oxidative damages of biomolecules specifically of DNA due to the accumulation of hydroperoxides and other ROS ultimately lead to the loss of cell viability or cell death through various death mechanisms like apoptosis, autophagy, necrosis, ferroptosis, and mitotic catastrophe (Fig