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The research was supported by the General Project of Natural science foundation project of Sichuan (2024NSFSC0599, 2023NSFSC0632), the Key Research and Development Program of Chengdu (2023-YF09-00052-SN), the Key Program of Development Fund for Clinical Disciplines of West China Second Hospital of Sichuan University (KL059), the General Project of National Natural Science Foundation of China (81971354), and the health department of Sichuan province (100377)