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In the absence of diabetes specialists, primary care physicians who may not be well-versed in the cardiovascular benefits of GLP-1 RAs could be hesitant to modify therapies when glycaemic control is stable, and feel reluctant to prescribe these medications even for patients with cardiovascular disease [23, 25]

Endothelial Heparan sulfate proteoglycans in Sepsis: the role of the Glycocalyx

To address this, we developed a chimeric GLP-1A that targets transporter-mediated endocytosis to enhance cellular permeability to GLP-1A by utilizing the transporters available in the intestine, particularly the apical sodium-dependent bile acid transporter (ASBT)

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