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Incretin-responsive human pancreatic adipose tissue organoids: A functional model for fatty pancreas research

Signals from the gut influence appetite, satiety, and energy balance through: The vagus nerve Hormonal signaling Microbial metabolites Key metabolic hormones produced or influenced by the gut include: GLP-1 (glucagon-like peptide-1) enhances insulin secretion and promotes satiety Peptide YY (PYY) signals fullness Ghrelin stimulates hunger When gut health is disrupted, these signals can become dysregulated, potentially contributing to overeating or impaired metabolic control

An oral version of the same sequence, if absorbed at all, would not necessarily retain that binding property after GI transit

ERK, Extracellular signal-regulated kinase