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7.5 Challenges in source, production, and formulation Some natural products are difficult to achieve clinical translation and widespread application due to scarce natural sources, challenging synthesis, or poor product consistency

In 1 study, a total of 572 black patients with moderate to severe hypertension were randomized to receive either combination amlodipine/valsartan or amlodipine monotherapy for 12 weeks

The production of ROS radicals (Figure 1) starts by the one electron reduction of oxygen (O 2 ) to O 2 which under the influence of the enzyme superoxide dismutase is converted to H 2 O 2

Understanding the role of mitochondrial dysfunction in fat metabolism and insulin resistance sheds light on the mechanisms underlying metabolic disorders and offers potential research targets