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The GutBrainMitochondria Axis in Autism The process can be understood as a biological cascade: Gut dysbiosis imbalance in the microbiome Leaky gut increased intestinal permeability Microbial metabolites enter the bloodstream Neuroinflammation and oxidative stress occur in the brain Mitochondrial dysfunction affects neuronal development This interconnected system helps explain why many children with ASD experience gastrointestinal symptoms, immune irregularities, and metabolic differences alongside neurological symptoms

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However, in the classic formulation of the ascorbateglutathione pathway (Foyer and Halliwell, 1976), DHA is reduced to ascorbate by the enzyme DHAR using reduced glutathione (GSH) as the reductant

Arsenic is a food chain contaminant and leads to severe health problems in the humans (Zhao et al., 2011)