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Because the dose starts conservatively, most patients do not experience maximum weight loss effects until they reach the target dose of 2.4 mg per week, which typically happens around month 4 to 5

Journal of the American Chemical Society 137 , 21282136, (2015)

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The baseline characteristics of the included female participants are presented in Table 1, and the differences in dietary vitamin B2 intake, femur BMD in different regions, and hip fracture frequency between OP and non-OP groups were reported in Table