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For instance, exendin-4 has been shown to ameliorate the high glucose-induced fibronectin (FN) and type I collagen (Col1) expression in tubular epithelial cells by inhibiting the secretion of miR-192, an microRNA (miRNA) that is regulated by p53 and plays a role in renal fibrosis (Li et al., 2018)
Rekha Kumar, an endocrinologist at Weill Cornell Medicine and senior medical adviser at Found Health, said the drugs have been a big breakthrough in the treatment of diabetes, but theyre still out of reach for many people who are uninsured, or whose insurance wont cover the prescriptions
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