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D51.3 - Other dietary vitamin B12 deficiency anemia: Used when macrocytic anemia is related to dietary vitamin B12 deficiency, not specifically due to malabsorption issues

If you're plant-based, you're likely low no matter how clean your diet is, so supplementation isn't optional

Phase Split option Daily dose 50 mg morning + 50 mg midday Notes Some sources prefer split AM dosing because the plasma half-life is short (about 4 to 7 hours in rodent PK)

Drug Interactions: Certain medications, like metformin and stomach acid reducers (PPIs), can interfere with B12 absorption from food, which may increase the need for injections