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[3] Afamelanotide was also found to sometimes induce darkening of certain pre-existing skin conditions, so regular full body skin examinations every 6 months is often recommended

Similarly, intestinal Zip8 KO mice exhibit systemic Mn deficiency and aggravated colitis, which can be rescued by inhibition of the downstream sphingolipid enzyme ACER1 (Melia et al., 2019)