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Methotrexate, a dihydrofolate reductase inhibitor, has reported G6PD-inhibitory effects (IC 50 of 114 M) 48 and antimalarial activity 49

It has also been named by Evaluate as one of the most anticipated drugs to be approved in 2022

Blood concentrations of -tocopherol are often used to assess vitamin E status, although concentrations should be adjusted for plasma lipid concentrations when lipids are elevated (28)

Exoxacin is the only fluoroquinolone in this series containing a naphthyridine group at the 8 th position suggesting the importance of this functional group in conferring radioprotection (Supplementary Fig