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For traumatic brain injury, the CAPTAIN program, summarized in a 2021 meta-analysis of two randomized trials and 185 patients, likewise reported modest benefit (Vester et al., 2021, pooled RCTs)

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Determination of LongR3-IGF-I, R3-IGF-I, Des1-3 IGF-I and their metabolites in human plasma samples by means of LCMS