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Trends Endocrinol Metab 25(1):4252 Nwia SM, Li XC, Leite APdO, Hassan R, Zhuo JL (2022) The Na+/H+ exchanger 3 in the intestines and the proximal tubule of the kidney: localization, physiological function, and key roles in angiotensin II-induced hypertension

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In the last subsection of this chapter, the utility of prodrugs is discussed in general and how GLP-1 based prodrugs could appropriately extend the biological half life and broaden the therapeutic index of GLP