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10.1038/nrn1344 5 BernhardsonB.-M.TishelmanC.RutqvistL

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Early work showed that Put, Spd, and Spm are enriched at synaptic terminals, but concluded that these polyamines are not themselves released as neurotransmitters (Seiler and Deckardt, 1976)

Together with their favorable effects on blood pressure, lipids, and overall cardiometabolic health, these mechanisms provide a biologically plausible explanation for the lower rates of limb events, hospitalization, and mortality that we observed. Akiva Rosenzveig, MD While our study cannot establish causation, the consistency of the findings across multiple clinically important outcomes supports the need for prospective randomized trials to confirm these benefits, Rosenzveig added