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With 17 DMTs available for the treatment of MS (Figure 1), clinicians are faced with the critical decision of how to screen MS patients for potential risk of malignancy with currently available DMTs and how to manage DMTs in MS patients who either had prior history of cancer or newly develop cancer while on a DMT

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On the other hand, AMPK signaling, a regulator of lipid metabolism and energy homeostasis, has been proven to limit the development and progression of osteoarthritis [16]