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According to 3 multicenter, randomized, double-blind, placebo-controlled obesity trials (BMI 30, or BMI 27 with at least 1 comorbidity of hypertension, dyslipidemia, or type 2 diabetes) conducted to evaluate the effect of CONTRAVE in conjunction with reduced caloric intake and increased physical activity, the average percentage of weight loss in patients at 56 weeks ranged from 3.7% to 8.1% with CONTRAVE, compared to 1.3% to 4.9% with placebo

However, factors like aging, poor diet, and certain health conditions can deplete glutathione levels in the body

Schindelin, J

A post-hoc SURPASS-4 kidney analysis found a meaningful reduction in a composite kidney endpoint compared to insulin glargine