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Regulatory safety review: FDA has identified serious adverse events including increased heart rate and systemic vasodilatory reaction, and has flagged concerns around immunogenicity, impurities, and limited data

ADVERSE EFFECTS In the cagrilintide, single-agent study between 2% and 6% (26%) of participants in the cagrilintide groups discontinued treatment prematurely because of adverse events, compared with 7% (7%) of participants in the liraglutide 3.0 mg group and 3% (3%) in the pooled placebo group

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