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Some common scenarios: Upgrading from semaglutide to tirzepatide: If youve plateaued on semaglutide or want to enhance results Trying semaglutide first: Some patients start with semaglutide and achieve their goals without needing to switch Managing side effects: If one medication causes intolerable side effects, the other may be better tolerated Switching medications requires medical supervision to ensure proper dosing and minimize side effects

Most recently, in October 2024, an updated ASA-led multisociety clinical practice guidance shifted toward a risk-stratified approach, highlighting prolonged fasting and optional POCUS evaluation rather than universal discontinuation of GLP-1 RAs [10]

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This is one of the most common times for nausea, vomiting, diarrhea, constipation, reflux, or abdominal discomfort to appear or temporarily worsen