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Valproic acid itself will slow gastric motility, so whole bowel irrigation may be most likely to succeed if initiated immediately following intubation (when drug levels are still relatively low)

Both tirzepatide and retatrutide activate GIPR, but tirzepatide is strictly a dual GIP/GLP-1 agonist while retatrutide additionally activates the glucagon receptor, classifying it as a triple agonist

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