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Side effects often return briefly with each dose increase but typically at a milder level than the initial adjustment period

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Other therapies were linked to increased adverse events such as stroke [11], hyperkalemia [13,15], hypotension [13], acute kidney injury (AKI) [15], and major adverse cardiovascular events (MACE) [14]

Additionally, DPP-4 inhibitors have been shown to improve abnormal liver transaminases levels such as aspartate aminotransferase and alanine transaminase, in patients with T2DM with liver dysfunction