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BDNF is a key regulator of neural plasticity, promoting synaptic strengthening, neuronal survival, and synaptogenesis, with particularly important effects in hippocampal regions involved in learning and memory (Numakawa et al., 2013)

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Samuels, a professor at the Oregon Clinical and Translational Research Institute, stated: It is a common clinical observation that some otherwise healthy patients with hypothyroidism continue to complain of fatigue, poor mood, inability to concentrate, and vague cognitive difficulties (often described as brain fog) despite normal TSH levels. [5] 2

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